IBUPROFEN

4/19/2016

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Some links about analgesic/anti-inflammatory ceiling doses: here and here.

Toni

4/26/2016 10:03:57 am

Hello.
I was chatting about the ibuprofen infogram with one of the consultants here (DCHFT). He's very interested to know where the ceiling dose of 400mg comes from (we give 800mg as a premed on the premed 'bundles' he wrote). Also if 400mg is the ceiling dose, would upping the max daily dose to 2.4g (from 1.6) not add anything?
Thanks for the fab info btw!

David link

4/30/2016 04:35:43 pm

Hi Toni - a couple of references for you!

Noting the difference between an anti-inflammatory ceiling and an analgesic ceiling. The analgesic ceiling seems to be 400mg, above which no further analgesic effect is noticed comes from literature comparing dosing.

The latter article (below) would say:
"For example, a single 200- to 400-mg dose of ibuprofen may reduce pain and fever, but daily consumption of 1600–2400 mg may be required to suppress inflammation adequately. Nevertheless, if we consider only their analgesic properties, the dose-response curves for nonopioids (NSAIDs and acetaminophen) exhibit a ceiling effect; additional increases in dose provide no further benefit."

http://socmob.org/2013/02/nsaids-part-2-the-ceiling-effect/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886920/

I hope this helps - if not, come on twitter and engage with Dr Motov (https://twitter.com/painfreeED) and myself (https://twitter.com/gas_craic)!

We'd love to hear more from you.

David

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USE OF THIS WEBSITE IS SUBJECT TO AGREEING TO THIS DISCLAIMER

THIS WEBSITE IS FOR HEALTHCARE PROFESSIONALS & STUDENTS ONLY