A glance at the literature from 2010-2018
A growing body of evidence and expert reviews suggests that we should be altering our administration regimes of beta-lactam and carbapenams to accommodate an altered volume of distribution (or RRT) status of the critically ill patient in order to more effectively reach the inhibitory concentrations of drug required to kill susceptible pathogens.
Don't forget you can catch the full trials at pubmed.gov and enter the PMID within the infographic.
HD FULLSCREEN HERE
PDF at bottom of page
PDF included at bottom of page for a clearer graphic (incl. 811 references!)
Fullscreen of the graphic below: here.
Dr. Sergey Motov (USA Emergency Medicine) & Dr. David Lyness (UK ICM/Anaesthetics)
UPDATE - NOVEMBER 2018
Taken from Dr Motov's work on a CERTA regime.
This is published in conjunction with the CERTA concept explanation here.
We can all provide superior analgesia by using medication and techniques other than just opioid medications.
This is NOT a definitive list and in all cases, local policies and protocols should be followed. Check your local formularies.
This is NOT a prescribing guideline - it is for EDUCATIONAL information ONLY.
We do not dispute the role of opioids in many spheres of practice, including emergency medicine, ICU and anaesthetics; rather we wish to highlight the pandemic of high opioid and opiate use. There are many medications available to reduce the amount of opioids used.
You may find, when considering your analgesia regimes that opioids are not always the best options for emergency pain issues.
We would advocate the use of nerve blocks in the first instance to control acute pain, when feasible.
With respect to alternatives listed for non-radicular back pain, it has been brought to our attention that a new study was presented in 2017 which showed that "diazepam has no benefit when added to naproxen vs placebo" in acute low back pain. See here.
This is a difficult document to see online - so I have included a fullscreen version here and the A3 printable PDF below.
There were 811 references when compiling this document; they can be found below....
PDF at bottom of page for best quality version.
Fullscreen HD here.
ALL of the trial abstracts are on PubMed.gov and can be found quickly by typing the PMID found in the reference below into its search field.
Download PDF at bottom of page.
PLEASE let me know if you see any errors and I will try to fix them ASAP.
HD Fullscreen of the infographs are at the bottom
PDF at bottom of page
I preface this infographic with the caveat that it is an exercise in discussion only, not an exhaustive or conclusive analysis of all systematic reviews within this time period. I have done my best to accurately analyse the trawled data - please do get in touch if you have any suggestions on improvements. I have no conflicts of interest and am not involved in any systematic reviews or trials with any organisation.
Adapted from a great article via EMCRIT by Dr. David Story (here)
PDF at bottom of page.
BETTER VIEWED IN:
PDF AT BOTTOM
These studies were found on PubMed and are ONLY the ones with completely #FOAMed access.
Interactive Version: FULLSCREEN HERE (HD Quality)
PDF file below
SEE ALL MY TRIAL SUMMARY DOCUMENTS HERE!
PDF at bottom.
A busy month, but a snapshot of some of the ICU trials of July 2018!
(Clearer graphic in the PDF below)
A snapshot of some of the major journal articles/trials in MAY 2018 for ICU
A snapshot of some of the major journal articles/trials in April 2018 for ICU
A snapshot of some of the major journal articles/trials in March 2018 for ICU
PDF DOWNLOAD (free)
And so the trend of monthly and annual summaries continues!
Here are some of the more memorable trials from February 2018 from ICU land. Hard to be completionist, or fit everything in one A4 page, but plenty of food for thought and continued discussion!
(Full Screen Here)
Below is an educational resource about how to begin to interpret ABG's and what the components seen on them mean in real-terms.
As always - not a clinical guideline, just a learning resource.
All lists are not exhaustive.
Note that many pathologies can cause a respiratory alkalosis via hyperventilation.
If you would like to print it out to use in a department, or as a teaching handout, please either let me know on Twitter, or email me at email@example.com - so I can keep a portfolio record.
*please note you can also use the mnemonic CAT-MUDPILES for the high anion gap causes - see here.
This is a four-page document outlining key considerations in the history taking, investigation and management of critically ill patients surrounding the time of discussion with the HDU/ICU team.
THIS IS A WORK IN PROGRESS - FEEL FREE TO CONTACT AND CONTRIBUTE!
1. It's a teaching & learning tool, rather than a document where people actually sit down and fill it in
2. It is intended to provide a structure/framework for thought processes around referrals to HDU/ICU
WHAT THIS IS RESOURCE IS NOT
These documents are NOT guidelines or policies and have not been ratified/tested for clinical use.
These documents do not replace the need for:
Seeking help immediately, if required
Clinical judgement and assessment
Discussing patient's with the patient's consultant (on-call)
'Referral algorithms' are a tricky business - which is why, this is not one - it's a learning resource, and not a clinical guideline or mandate. Documents and checklists should not prevent you from seeking skilled help early. The documents do suggest things you should be mindful of, in sick patients.
It is impossible to predict every eventuality - but many of these principles are ubiquitous to all referrals.
With thanks given to Dr. Jonny Wilkinson, Dr. Adrian Wong and Dr Segun Olusanya for their thoughts on this project, as well as to everyone who has already commented on Twitter.
Hover over the infograph below and you will see four slides of content you can peruse through.
PDF Download Available here.
Some interesting trials are promised in 2018.
Here are some of the more interesting ones (mostly SR's) that sprang up over January 2018...
As always, these are to provoke discussion on twitter, rather than me or anyone else giving a definitive 'what do I think' on them. Head on over to the websites mentioned at the bottom of the infographic to see some excellent commentaries on other trials. Particularly www.thebottomline.org.uk
ADRENAL was launched at Critical Care Reviews in January 2018.
The rest that I have featured are systematic reviews.
Many thanks to all publishers, authors and researchers who endeavour to make their research free to access to the #FOAMed community.
LINKS TO THE STUDIES/SR's
GLYCAEMIC CONTROL IN TBI
INTUBATION IN THE CRITICALLY ILL
PROPOFOL FOR SLEEP IN ADULT ICU PATIENTS
CLICK HERE TO SEE THIS FULL-SCREEN
It has certainly been a year of great #FOAMed for Critical Care and Anaesthetics...
In this short round-up of the Propofological year - we look at 10 topics of the year as well as projects I've been involved in, infographics we've created, podcasts, YouTube channel, #IFAD2017 and perhaps talk about some of what's to come in 2018.
1. SEPSIS 3.000000 - is still here...! Seems to be at every conference I attend!
2. POCUS - a fan favourite in the community. More people picking up the probe this year! A great deal of excellent resources popping up all over the place. Critical Care Northampton have excellent resources for POCUS-mad practitioners!
3. Fluid Management (less seems to be more?) - #IFAD2017 hammered home the need to REALLY think about fluid prescriptions in the critically ill. They highlighted sepsis is primarily a condition of vasoplegia where patients may also require fluid... it's not solely a problem of hypovolaemia. This probably ties in with our own experiences with IV fluids where there is, in many conditions, a resus phase, plateau and de-resuscitation phase. Such is the scale of the problem we came together and developed a protocol for fluid prescription focusing on the four D's... IV FLUID PROTOCOL
4. Renal Issues - bicarb/NAC protection is a bit of a myth when it comes to IV contrast. We may not have been blown away by the outcome of the PRESERVE trial, but it certainly helped to confirm suspicions.
5. A fascinating sepsis trial in Zambia increase focus onto current sepsis management in developing countries. Not generally applicable to developed countries population, but still enormous amount of food for thought and a lot of interesting data. Many patients were HIV positive, and the inotrope used was dopamine (cheap and widely available). Lots of questions remain to be answered (and asked) about why this protocol performed so badly vs standard care.
6. Presentation skills at conferences still leave a lot to be desired. At nearly every conference, I could imagine Mr Ross Fisher's despairing face, wailing at the presenter for reading out endless slides of boring data. A key piece of advice would be that people do not come for you to read them your data, they come to hear your opinion on your data. Provide articles in advance, provide data in advance and deliver a TALK to your audience. More about P3 presentation skills here by Ross Fisher...
7. Opioid alternative regimes are still interesting a vast number of practitioners out there. I published a list of alternatives with Dr. Sergey Motov in 2016, which vent viral at this year's @Core_EM via Dr. Anand Swaminathan. You can see it here along with the 'concept' here. Perhaps one of the things I would like to mention about this piece of work is that they are SUGGESTIONS for opioid alternatives. We would hate to be labelled as zealots when it comes to an anti-opioid stance - it would be foolish not to recognise the important role of opioids as an analgesic - particularly when I use them in anaesthetics every day! But it would be equally foolish to approach all pain-types with opioids. There is an evidence base that Dr Motov has ploughed into and referenced for this resource, and it does require an update in 2018 (given new evidence about diazepam in back pain etc.) - which will be coming up in January! There is also plenty of room for multi-modal analgesia within many specialties.
8. A little more about #IFAD2017. Many thanks to the wonderful Prof. Manu Malbrain for inviting me to form part of the core faculty at IFAD this year. He is an inspirational man and a phenomenal host, who really understands the power of social media in intensive care medicine. Unapologetic of his technological stance when it comes to a fairly traditional conference, he has revolutionised this event and made more than 24 million impressions via Twitter, world-wide as well as boosting real-term participation of the conference by up to 1000 extra via webinars and online interaction. The material that was curated by the social media team is still being used at this moment by people across Twitter and the internet. I look forward to joining him again for the next event.
9. Born out of the IFAD social media team was a group of us who wanted to move forward together in critical care #FOAMed and develop a new and exciting project which will bring us a new and exciting style of critical care conference in the UK.... more on this in 2018.
10. Discussions ebb and flow in Twitterland, some of them more tiresome that others. A desire to move on from discussions over DL vs VL and Sux vs Roc is growing and hopefully will continue to flourish into 2018. Having spoken about this in some of our podcasts, I think a good proverb may be, for many, many, many aspects of medicine; "There are many ways to skin a cat". Often, it's good to disagree - but - sometimes it's better to just move on and discuss something else... at least for a while.
Below are some great resources to highlight some of the efforts that have dominated my own year in educational material:
Infographs on Cardiac Arrest, Opioid Alternatives, Rib Fracture Management and IV Fluid Constituents were amongst the popular of 2017 for Propofology followers. You can see a full list of the infograms here.
The Propofology/QuickMedic YouTube channel continues to grow with free content. Check out one of our first videos in 2017 here... many more on the channel!
The summary that I have made of the top #FOAMed trials for ICU is available in infogram form, here.
www.CriticalCareNorthampton.com by Dr. Jonny Wilkinson continues to provide excellent blog posts, trawling the net for excellent critical care articles and projects. We have collaborated extensively this year with #IFAD2017 and in other projects to bring some excellent material to the fore. We hope you have enjoyed this as much as we have. Jonny has my particular thanks this year as being a wonderful contributor to Propofology projects as well as getting us involved in as many different aspects of #FOAMed as practically possible. Check out some of our stuff:
IV FLUID PROTOCOL
STOP BEFORE YOU BLOCK
#IFAD2017 QUOTES & GRAPHICS
#ICSSOA2017 QUOTES AND GRAPHICS
TheBottomLine from the Wessex Deanery created a brilliant review of their top ten trials from 2017. I collated them in an infographic here, but check them out for yourself!
CriticalCareReviews.com has its latest meeting in JANUARY of 2018! Lots of #FOAMed content to come from that. You can see all the old content from 2017 (still extremely relevant) here.
Propofology will continue to be a site of resource curation and promote social media in medical education to all levels of practitioners, in all corners of the world.
Have a wonderful new year everyone. Be kind to each other. Thanks so much for everyone's support of the Propofological endeavours throughout 2017... there will be many more in 2018.
Here is a compilation of some of the major trials in 2017 for ICU.
You can see many of them in the HOT ARTICLES section of the phenomenal CriticalCareReviews.com
You can see many of them reviewed on www.TheBottomLine.org.uk as well as our partner website www.CriticalCareNorthampton.com
The references for all of these trials can be found in the various months here or via a quick google search.
We encourage you ALL to read the trials and decide for yourself - these are not individual reviews and merely summarise what the authors themselves have stated in their trial. The idea of infographics like this is, that via a quick read, you can identify some good #FOAMed articles that may peak your interest and you can explore them further. They also serve as good reminders to what goes on in a busy academic year.
(Please print out the document without alterations - keeping the websites etc on the page)
I was delighted when TheBottomLine did a best of the best review of their ICU trial summaries this year.
I have collated them below in an infographic. You have to check out their website to have a good look at all of the tremendous work they've done in more detail! CLICK HERE
Merry Xmas & Happy New Year!
Following on from our previous post on our IV fluid protocol (here). We would LOVE to hear your ideas for it's implantation and development in the coming weeks, months and years.
Have a listen to our Podcast where we discuss how the project came about, the problem with IV Fluid prescribing and our call to action to get a similar idea installed in a trust near you.
Even more documents and tables coming soon!
Please, if you do want to use our material please attribute it to us so we can show others amazing #FOAMed resources. Also, do let us know! We'd be delighted to hear from you.
Don't forget to check out the rest of the Propofology Podcasts here.
Check out the updated CriticalCareNorthampton.com blog too!
A joint collaboration from Dr. Jonny Wilkinson and Dr. David Lyness for International Fluid Academy.
Here we present Dr. Wilkinson & Dr Abdul Gomaa's excellent work on establishing a FLUID PROTOCOL for patients, establishing key processes within the prescription and considerations of IV fluids in the hospital.
Both of us are attending Internation Fluid Academy in Belgium this year (#IFAD2017) as Faculty. This is a high-end academic conference in Intensive Care Medicine that will have a heavy social media presence - focusing on fluid management, haemodynamics, POCUS and ICU management of the patient in fluid excess.
As with ALL FOAMed material, this protocol is for information only and we cannot take any responsibility for its use outside our spheres of practice. Nevertheless, it is enough to give you plenty of food for thought in creating your own flow-sheets in your own hospitals.
PS: The image is below, but you can see it in high definition and full-screen using this link here.
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